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Acute coronary syndrome

MedGen UID:
215295
Concept ID:
C0948089
Disease or Syndrome
Synonyms: Acute Coronary Syndrome; Acute Coronary Syndromes; Coronary Syndrome, Acute; Coronary Syndromes, Acute; Syndrome, Acute Coronary; Syndromes, Acute Coronary
SNOMED CT: Acute coronary syndrome (394659003); ACS - Acute coronary syndrome (394659003)
 
HPO: HP:0033678
Monarch Initiative: MONDO:0005542

Definition

The term acute coronary syndrome (ACS) refers to any group of clinical symptoms compatible with acute myocardial ischemia and includes unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI). [from HPO]

Professional guidelines

PubMed

Joglar JA, Chung MK, Armbruster AL, Benjamin EJ, Chyou JY, Cronin EM, Deswal A, Eckhardt LL, Goldberger ZD, Gopinathannair R, Gorenek B, Hess PL, Hlatky M, Hogan G, Ibeh C, Indik JH, Kido K, Kusumoto F, Link MS, Linta KT, Marcus GM, McCarthy PM, Patel N, Patton KK, Perez MV, Piccini JP, Russo AM, Sanders P, Streur MM, Thomas KL, Times S, Tisdale JE, Valente AM, Van Wagoner DR; Peer Review Committee Members
Circulation 2024 Jan 2;149(1):e1-e156. Epub 2023 Nov 30 doi: 10.1161/CIR.0000000000001193. PMID: 38033089Free PMC Article
Virani SS, Newby LK, Arnold SV, Bittner V, Brewer LC, Demeter SH, Dixon DL, Fearon WF, Hess B, Johnson HM, Kazi DS, Kolte D, Kumbhani DJ, LoFaso J, Mahtta D, Mark DB, Minissian M, Navar AM, Patel AR, Piano MR, Rodriguez F, Talbot AW, Taqueti VR, Thomas RJ, van Diepen S, Wiggins B, Williams MS; Peer Review Committee Members
Circulation 2023 Aug 29;148(9):e9-e119. Epub 2023 Jul 20 doi: 10.1161/CIR.0000000000001168. PMID: 37471501
Gulati M, Levy PD, Mukherjee D, Amsterdam E, Bhatt DL, Birtcher KK, Blankstein R, Boyd J, Bullock-Palmer RP, Conejo T, Diercks DB, Gentile F, Greenwood JP, Hess EP, Hollenberg SM, Jaber WA, Jneid H, Joglar JA, Morrow DA, O'Connor RE, Ross MA, Shaw LJ
Circulation 2021 Nov 30;144(22):e368-e454. Epub 2021 Oct 28 doi: 10.1161/CIR.0000000000001029. PMID: 34709879

Curated

UK NICE guideline NG185, Acute coronary syndromes, 2020

Recent clinical studies

Etiology

Nohria R, Viera AJ
Am Fam Physician 2024 Jan;109(1):34-42. PMID: 38227869
Damluji AA, Forman DE, Wang TY, Chikwe J, Kunadian V, Rich MW, Young BA, Page RL 2nd, DeVon HA, Alexander KP; American Heart Association Cardiovascular Disease in Older Populations Committee of the Council on Clinical Cardiology and Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; and Council on Lifestyle and Cardiometabolic Health
Circulation 2023 Jan 17;147(3):e32-e62. Epub 2022 Dec 12 doi: 10.1161/CIR.0000000000001112. PMID: 36503287Free PMC Article
Mehilli J, Presbitero P
Heart 2020 Apr;106(7):487-492. Epub 2020 Jan 13 doi: 10.1136/heartjnl-2019-315555. PMID: 31932287
Hedayati T, Yadav N, Khanagavi J
Cardiol Clin 2018 Feb;36(1):37-52. doi: 10.1016/j.ccl.2017.08.003. PMID: 29173680
Smith JN, Negrelli JM, Manek MB, Hawes EM, Viera AJ
J Am Board Fam Med 2015 Mar-Apr;28(2):283-93. doi: 10.3122/jabfm.2015.02.140189. PMID: 25748771

Diagnosis

Nohria R, Antono B
Prim Care 2024 Mar;51(1):53-64. Epub 2023 Aug 26 doi: 10.1016/j.pop.2023.07.003. PMID: 38278573
Damluji AA, Forman DE, Wang TY, Chikwe J, Kunadian V, Rich MW, Young BA, Page RL 2nd, DeVon HA, Alexander KP; American Heart Association Cardiovascular Disease in Older Populations Committee of the Council on Clinical Cardiology and Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; and Council on Lifestyle and Cardiometabolic Health
Circulation 2023 Jan 17;147(3):e32-e62. Epub 2022 Dec 12 doi: 10.1161/CIR.0000000000001112. PMID: 36503287Free PMC Article
Atwood J
Emerg Med Clin North Am 2022 Nov;40(4):693-706. doi: 10.1016/j.emc.2022.06.008. PMID: 36396216
Mehilli J, Presbitero P
Heart 2020 Apr;106(7):487-492. Epub 2020 Jan 13 doi: 10.1136/heartjnl-2019-315555. PMID: 31932287
Hedayati T, Yadav N, Khanagavi J
Cardiol Clin 2018 Feb;36(1):37-52. doi: 10.1016/j.ccl.2017.08.003. PMID: 29173680

Therapy

Cho K, Kim M
Gen Hosp Psychiatry 2023 Sep-Oct;84:215-225. Epub 2023 Aug 15 doi: 10.1016/j.genhosppsych.2023.08.003. PMID: 37619300
Kite TA, Kurmani SA, Bountziouka V, Cooper NJ, Lock ST, Gale CP, Flather M, Curzen N, Banning AP, McCann GP, Ladwiniec A
Eur Heart J 2022 Sep 1;43(33):3148-3161. doi: 10.1093/eurheartj/ehac213. PMID: 35514079Free PMC Article
Carson JL, Stanworth SJ, Dennis JA, Trivella M, Roubinian N, Fergusson DA, Triulzi D, Dorée C, Hébert PC
Cochrane Database Syst Rev 2021 Dec 21;12(12):CD002042. doi: 10.1002/14651858.CD002042.pub5. PMID: 34932836Free PMC Article
Gulati M, Levy PD, Mukherjee D, Amsterdam E, Bhatt DL, Birtcher KK, Blankstein R, Boyd J, Bullock-Palmer RP, Conejo T, Diercks DB, Gentile F, Greenwood JP, Hess EP, Hollenberg SM, Jaber WA, Jneid H, Joglar JA, Morrow DA, O'Connor RE, Ross MA, Shaw LJ
Circulation 2021 Nov 30;144(22):e368-e454. Epub 2021 Oct 28 doi: 10.1161/CIR.0000000000001029. PMID: 34709879
Carson JL, Grossman BJ, Kleinman S, Tinmouth AT, Marques MB, Fung MK, Holcomb JB, Illoh O, Kaplan LJ, Katz LM, Rao SV, Roback JD, Shander A, Tobian AA, Weinstein R, Swinton McLaughlin LG, Djulbegovic B; Clinical Transfusion Medicine Committee of the AABB
Ann Intern Med 2012 Jul 3;157(1):49-58. doi: 10.7326/0003-4819-157-1-201206190-00429. PMID: 22751760

Prognosis

Caidahl K, Hartford M, Ravn-Fischer A, Lorentzen E, Yndestad A, Karlsson T, Aukrust P, Ueland T
J Am Coll Cardiol 2019 Aug 13;74(6):774-782. doi: 10.1016/j.jacc.2019.06.030. PMID: 31395128
Ricci B, Cenko E, Vasiljevic Z, Stankovic G, Kedev S, Kalpak O, Vavlukis M, Zdravkovic M, Hinic S, Milicic D, Manfrini O, Badimon L, Bugiardini R
J Am Heart Assoc 2017 Dec 22;6(12) doi: 10.1161/JAHA.117.007519. PMID: 29273636Free PMC Article
Tofler GH, Kopel E, Klempfner R, Eldar M, Buckley T, Goldenberg I; National Israel Survey of Acute Coronary Syndrome Investigators
Am J Cardiol 2017 May 15;119(10):1560-1565. Epub 2017 Mar 1 doi: 10.1016/j.amjcard.2017.02.022. PMID: 28377021
Giugliano RP, Braunwald E
J Am Coll Cardiol 2014 Jan 28;63(3):201-14. Epub 2013 Nov 13 doi: 10.1016/j.jacc.2013.10.041. PMID: 24239661
Carson JL, Brooks MM, Abbott JD, Chaitman B, Kelsey SF, Triulzi DJ, Srinivas V, Menegus MA, Marroquin OC, Rao SV, Noveck H, Passano E, Hardison RM, Smitherman T, Vagaonescu T, Wimmer NJ, Williams DO
Am Heart J 2013 Jun;165(6):964-971.e1. Epub 2013 Apr 8 doi: 10.1016/j.ahj.2013.03.001. PMID: 23708168Free PMC Article

Clinical prediction guides

Wagener M, Twerenbold R, Zellweger MJ, Haaf P
Int J Cardiovasc Imaging 2023 Jun;39(6):1179-1180. Epub 2023 Mar 13 doi: 10.1007/s10554-023-02813-1. PMID: 36913156Free PMC Article
Camaro C, Aarts GWA, Adang EMM, van Hout R, Brok G, Hoare A, Rodwell L, de Pooter F, de Wit W, Cramer GE, van Kimmenade RRJ, Damman P, Ouwendijk E, Rutten M, Zegers E, van Geuns RM, Gomes MER, van Royen N
Eur Heart J 2023 May 14;44(19):1705-1714. doi: 10.1093/eurheartj/ehad056. PMID: 36755110Free PMC Article
Bharmal M, Kern MJ, Kumar G, Seto AH
Curr Cardiol Rep 2022 May;24(5):541-550. Epub 2022 Mar 2 doi: 10.1007/s11886-022-01675-8. PMID: 35235145Free PMC Article
Kumar V, Weerakoon S, Dey AK, Earls JP, Katz RJ, Reiner JS, Shaw LJ, Blankstein R, Mehta NN, Choi AD
J Cardiovasc Comput Tomogr 2021 Sep-Oct;15(5):384-393. Epub 2021 Feb 23 doi: 10.1016/j.jcct.2021.02.002. PMID: 33858808
Poldervaart JM, Langedijk M, Backus BE, Dekker IMC, Six AJ, Doevendans PA, Hoes AW, Reitsma JB
Int J Cardiol 2017 Jan 15;227:656-661. Epub 2016 Oct 30 doi: 10.1016/j.ijcard.2016.10.080. PMID: 27810290

Recent systematic reviews

Faro DC, Laudani C, Agnello FG, Ammirabile N, Finocchiaro S, Legnazzi M, Mauro MS, Mazzone PM, Occhipinti G, Rochira C, Scalia L, Spagnolo M, Greco A, Capodanno D
JACC Cardiovasc Interv 2023 Oct 9;16(19):2347-2364. doi: 10.1016/j.jcin.2023.07.043. PMID: 37821180
Cho K, Kim M
Gen Hosp Psychiatry 2023 Sep-Oct;84:215-225. Epub 2023 Aug 15 doi: 10.1016/j.genhosppsych.2023.08.003. PMID: 37619300
Astarita A, Covella M, Vallelonga F, Cesareo M, Totaro S, Ventre L, Aprà F, Veglio F, Milan A
J Hypertens 2020 Jul;38(7):1203-1210. doi: 10.1097/HJH.0000000000002372. PMID: 32510905
Fanaroff AC, Rymer JA, Goldstein SA, Simel DL, Newby LK
JAMA 2015 Nov 10;314(18):1955-65. doi: 10.1001/jama.2015.12735. PMID: 26547467
Carson JL, Grossman BJ, Kleinman S, Tinmouth AT, Marques MB, Fung MK, Holcomb JB, Illoh O, Kaplan LJ, Katz LM, Rao SV, Roback JD, Shander A, Tobian AA, Weinstein R, Swinton McLaughlin LG, Djulbegovic B; Clinical Transfusion Medicine Committee of the AABB
Ann Intern Med 2012 Jul 3;157(1):49-58. doi: 10.7326/0003-4819-157-1-201206190-00429. PMID: 22751760

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE guideline NG185, Acute coronary syndromes, 2020

    Consumer resources

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